{"id":4146,"date":"2025-10-15T19:47:21","date_gmt":"2025-10-15T11:47:21","guid":{"rendered":"https:\/\/www.15zhi.net\/blog\/?p=4146"},"modified":"2025-10-15T19:47:21","modified_gmt":"2025-10-15T11:47:21","slug":"202510-%e8%ae%ba%e6%96%87%e7%a0%94%e8%af%bb-mragent-an-llm-based-automated-agent-for-causal-knowledge-discovery-in-disease-via-mendelianrandomization","status":"publish","type":"post","link":"https:\/\/www.15zhi.net\/blog\/202510-%e8%ae%ba%e6%96%87%e7%a0%94%e8%af%bb-mragent-an-llm-based-automated-agent-for-causal-knowledge-discovery-in-disease-via-mendelianrandomization\/","title":{"rendered":"202510 \u8bba\u6587\u7814\u8bfb-MRAgent: an LLM-based automated agent for causal knowledge discovery in disease via Mendelianrandomization"},"content":{"rendered":"\n

\u6765\u6e90\uff1aBriefings in Bioinformatics<\/p>\n\n\n\n

\u4f5c\u8005\uff1aWei Xu\u3001Gang Luo\u3001Weiyu Meng\u3001Xiaobing Zhai\u7b49<\/p>\n\n\n\n

\u5355\u4f4d\uff1a\u6fb3\u95e8\u7406\u5de5\u5927\u5b66\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u8f6f\u4ef6\u7814\u7a76\u6240\u8ba1\u7b97\u673a\u79d1\u5b66\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u7b49<\/p>\n\n\n\n

\u53d1\u8868\u65f6\u95f4\uff1a 2025\u5e7402\u6708<\/p>\n\n\n\n

\u4e00\u3001\u8bba\u6587\u4ecb\u7ecd<\/h2>\n\n\n\n

\u80cc\u666f\uff1a\u533b\u5b66\u7814\u7a76\u4e2d\u56e0\u679c\u63a8\u65ad\u81f3\u5173\u91cd\u8981\uff0c\u4f46\u4f20\u7edf\u65b9\u6cd5\u4f9d\u8d56\u4e34\u5e8a\u7ecf\u9a8c\u548c\u6587\u732e\u56de\u987e\uff0c\u8fc7\u7a0b\u7e41\u7410\u4e14\u6613\u9057\u6f0f\u4fe1\u606f\u3002<\/p>\n\n\n\n


\u6838\u5fc3\uff1a \u57fa\u4e8e\u8fd9\u4e00\u80cc\u666f\uff0c\u8bba\u6587\u63d0\u51fa\u4e86MRAgent\u6846\u67b6\uff0c\u5229\u7528LLM\u81ea\u52a8\u4ece\u79d1\u5b66\u6587\u732e\u4e2d\u63d0\u53d6\u6f5c\u5728\u7684\u66b4\u9732-\u7ed3\u679c\u5bf9\uff0c\u5e76\u5229\u7528\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u6570\u636e\u8fdb\u884cMR\u56e0\u679c\u63a8\u65ad\u3002MRAgent\u80fd\u591f\u81ea\u52a8\u5316\u5730\u5b8c\u6210\u4ece\u6587\u732e\u68c0\u7d22\u5230\u56e0\u679c\u5206\u6790\u7684\u5168\u8fc7\u7a0b\uff0c\u663e\u8457\u63d0\u9ad8\u4e86\u56e0\u679c\u77e5\u8bc6\u53d1\u73b0\u7684\u6548\u7387\u548c\u51c6\u786e\u6027\uff0c\u4e3a\u533b\u5b66\u7814\u7a76\u63d0\u4f9b\u4e86\u4e00\u4e2a\u5f3a\u5927\u7684\u81ea\u52a8\u5316\u5de5\u5177\u3002<\/p>\n\n\n\n

\u4e8c\u3001\u5c55\u793a LLM \u9a71\u52a8\u7684\u56e0\u679c\u5206\u6790\u7cfb\u7edf\u67b6\u6784<\/h2>\n\n\n\n
    \n
  1. MRAgent\u7684\u4e09\u5c42\u7ed3\u6784\uff1aBrain\uff08\u667a\u80fd\u51b3\u7b56\uff09\u3001Memory\uff08\u6570\u636e\u8868\u8bb0\u5fc6\uff09\u3001Toolkit\uff08\u6267\u884c\u5de5\u5177\uff09<\/li>\n\n\n\n
  2. LLM\u8d1f\u8d23\u63a7\u5236\u6574\u4e2a\u6d41\u7a0b\uff0c\u7c7b\u4f3c\u7814\u7a76\u8005\u601d\u8003\u2014\u884c\u52a8\u7684\u5faa\u73af<\/li>\n\n\n\n
  3. \u8fd9\u662f\u7cfb\u7edf\u7684\u6838\u5fc3\u903b\u8f91\u56fe\uff0c\u4f53\u73b0\u4ece\u8f93\u5165\u75be\u75c5\u5230\u8f93\u51fa\u56e0\u679c\u63a8\u65ad\u7684\u5168\u6d41\u7a0b<\/li>\n<\/ol>\n\n\n\n
    \"\"<\/figure>\n\n\n\n

    \u8fd9\u662f\u6574\u7bc7\u8bba\u6587\u7684\u6280\u672f\u6838\u5fc3\uff0c\u5c55\u793a\u4e86\u4f5c\u8005\u63d0\u51fa\u7684 MRAgent \u7cfb\u7edf\u7684\u7ed3\u6784\u3002\u5b83\u57fa\u4e8eLLM\uff0c\u5b9e\u73b0\u4ece\u6d77\u91cf\u6587\u732e\u4e2d\u81ea\u52a8\u63d0\u53d6\u3001\u6bd4\u5bf9\u3001\u9a8c\u8bc1\u201c\u66b4\u9732\u2013\u7ed3\u679c\u201d\u56e0\u679c\u5bf9\u3002\u6a21\u5757\u5305\u62ec\u6587\u672c\u9884\u5904\u7406\u3001\u56e0\u679c\u5bf9\u8bc6\u522b\u3001\u8bc1\u636e\u9a8c\u8bc1\u548c\u8f93\u51fa\u53ef\u4fe1\u5ea6\u8bc4\u4f30\u3002<\/p>\n\n\n\n

    \u5bf9\u6bd4\u4f20\u7edfMR\u5206\u6790\u6d41\u7a0b\u4e0eMRAgent\u81ea\u52a8\u5316\u6d41\u7a0b<\/strong><\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    \u5de6\u56fe\u5c55\u793a\u4e86\u4f20\u7edfMR\u5206\u6790\u7684\u4eba\u5de5\u6d41\u7a0b\uff0c\u5305\u62ec\u624b\u52a8\u6587\u732e\u68c0\u7d22\u3001\u56e0\u679c\u5bf9\u8bc6\u522b\u3001GWAS\u6570\u636e\u9009\u62e9\u548cMR\u5206\u6790\u3002\u53f3\u56fe\u5c55\u793a\u4e86MRAgent\u7684\u81ea\u52a8\u5316\u6d41\u7a0b\uff0c\u4ece\u6587\u732e\u68c0\u7d22\u5230MR\u5206\u6790\u7684\u5168\u8fc7\u7a0b\u7531LLM\u9a71\u52a8\u3002
    \u5f15\u5165\u4e00\u4e2a\u201c\u5931\u8d25\u91cd\u8bd5\u673a\u5236\u201d\uff08\u4f8b\u5982\u67d0\u4e2a\u53cd\u4e8b\u5b9e\u9a8c\u8bc1\u672a\u901a\u8fc7\uff0c\u91cd\u65b0\u8c03\u6574\u878d\u5408\u6743\u91cd\u518d\u9a8c\u8bc1\uff09\u3002\u8ba9 LLM \u6839\u636e\u6536\u655b\u5ea6\u6216\u5171\u8bc6\u6bd4\u52a8\u6001\u8c03\u6574Prompt\u6216\u6743\u91cd\u53c2\u6570\u3002<\/p>\n\n\n\n

    \u5c55\u793a\u6807\u6ce8\u7b56\u7565\u4e0e\u6570\u636e\u51b3\u7b56\u903b\u8f91<\/strong><\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    \u4eba\u5de5\u6807\u6ce8\u51b3\u7b56\u6811\u901a\u8fc7\u4e24\u5c42\u5224\u65ad\uff08\u662f\u5426\u4e0e\u6587\u7ae0\u4e00\u81f4\u3001\u662f\u5426\u4e0e\u5173\u952e\u8bcd\u76f8\u5173\uff09\uff0c\u5c06\u6587\u732e\u4e2d\u7684\u8bc1\u636e\u5206\u4e3a\u4e09\u7c7b\uff1aLabel A\uff08\u6838\u5fc3\u8bc1\u636e\uff09\u3001Label B\uff08\u8865\u5145\u8bc1\u636e\uff09\u548cLabel C\uff08\u6392\u9664\uff09\u3002<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    \u6807\u7b7e\u51b3\u7b56\u6811\u7684\u5177\u4f53\u5e94\u7528\u6848\u4f8b\uff0c\u4ee5\u201cLung Cancer (LC)\u201d\u4e3a\u5173\u952e\u8bcd\uff0c\u5c55\u793a\u4e86\u4e00\u7bc7PubMed\u6587\u732e\u4e2d\u66b4\u9732-\u7ed3\u679c\u5bf9\u7684\u6807\u7b7e\u7ed3\u679c\uff1a
    Label A\uff1a\u5982\u201cCXCL5\uff08\u66b4\u9732\uff09\u2192NSCLC\uff08\u7ed3\u679c\uff09\u201d\uff0c\u65e2\u7b26\u5408\u6587\u7ae0\u4e3b\u9898\uff08\u80ba\u764c\u8fdb\u5c55\uff09\uff0c\u53c8\u4e0e\u5173\u952e\u8bcd\u5f3a\u76f8\u5173\uff1b
    Label B\uff1a\u5982\u201cCXCL5\u4ee3\u8c22\u7269\uff08\u66b4\u9732\uff09\u2192\u6cbb\u7597\u7ed3\u5c40\uff08\u7ed3\u679c\uff09\u201d\uff0c\u867d\u4e0e\u6587\u7ae0\u76f8\u5173\u4f46\u4e0e\u201cLung Cancer\u201d\u5173\u952e\u8bcd\u5173\u8054\u8f83\u5f31\uff1b
    Label C\uff1a\u5982\u201cNETosis\uff08\u66b4\u9732\uff09\u2192CD8 T\u7ec6\u80de\u529f\u80fd\u969c\u788d\uff08\u7ed3\u679c\uff09\u201d\uff1f\uff08\u6ce8\uff1a\u56fe\u4e2d\u793a\u4f8b\u4e2d\u201cNETosis in neutrophils\u201d\u4f5c\u4e3a\u66b4\u9732\u3001\u201cCD8 T cell dysfunction\u201d\u4f5c\u4e3a\u7ed3\u679c\uff0c\u5b9e\u9645\u5e94\u5c5e\u4e8eLabel A\uff0c\u9700\u7ed3\u5408\u4e0a\u4e0b\u6587\u786e\u8ba4\uff0c\u6b64\u5904\u6309\u56fe\u793a\u903b\u8f91\u8bf4\u660e\uff09<\/p>\n\n\n\n

    \u4e09\u3001\u5b9e\u9645\u5e94\u7528\u6848\u4f8b\uff08\u4f4e\u80cc\u75db\u7814\u7a76\uff09\u5c55\u793a\u5b8c\u6574\u6d41\u7a0b\u4e0e\u6700\u7ec8\u56e0\u679c\u7ed3\u8bba<\/h2>\n\n\n\n
    \"\"<\/figure>\n\n\n\n

    \u901a\u8fc7\u4e00\u4e2a\u4f4e\u80cc\u75db\u7814\u7a76\u6848\u4f8b\uff0c\u5c55\u793a\u4e86MRAgent\u5982\u4f55\u4ece\u6587\u732e\u4e2d\u63d0\u53d6\u56e0\u679c\u5bf9\u5e76\u8fdb\u884cMR\u5206\u6790\u3002\u5728\u8fd9\u4e2a\u6848\u4f8b\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u8f93\u5165\u201cOutcome: back pain\u201d\uff08\u7ed3\u679c\uff1a\u80cc\u75db\uff09\uff0cMRAgent\u81ea\u52a8\u68c0\u7d22\u76f8\u5173\u6587\u732e\uff0c\u63d0\u53d6\u4e0e\u80cc\u75db\u76f8\u5173\u7684\u66b4\u9732\u56e0\u7d20\uff08\u5982\u201cspondylolysis\u201d\u5373\u810a\u690e\u6ed1\u8131\uff09\uff0c\u5e76\u8bc6\u522b\u51fa\u6f5c\u5728\u7684\u56e0\u679c\u5bf9\u3002\u968f\u540e\uff0cMRAgent\u5229\u7528GWAS\u6570\u636e\u5bf9\u8fd9\u4e9b\u56e0\u679c\u5bf9\u8fdb\u884cMR\u5206\u6790\uff0c\u6700\u7ec8\u5f97\u51fa\u7ed3\u8bba\uff1a\u810a\u690e\u6ed1\u8131\u4e0e\u6162\u6027\u4f4e\u80cc\u75db\u4e4b\u95f4\u5b58\u5728\u56e0\u679c\u5173\u7cfb\u3002\u8fd9\u4e2a\u6848\u4f8b\u8bc1\u660e\u4e86MRAgent\u5728\u81ea\u52a8\u5316\u56e0\u679c\u77e5\u8bc6\u53d1\u73b0\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b9e\u7528\u6027\uff0c\u80fd\u591f\u5feb\u901f\u4ece\u6d77\u91cf\u6587\u732e\u4e2d\u6316\u6398\u51fa\u6709\u4ef7\u503c\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u4e3a\u533b\u5b66\u7814\u7a76\u548c\u4e34\u5e8a\u5b9e\u8df5\u63d0\u4f9b\u652f\u6301\u3002<\/p>\n\n\n\n

    \u56db\u3001\u5b9e\u9a8c<\/h2>\n\n\n\n

    \u5728\u4e0d\u540c\u6a21\u578b\u7684\u8bc6\u522b\u7ed3\u679c\u4e0e\u76f8\u4f3c\u5ea6\uff1b<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    \u8bc6\u522b\u662f\u5426\u5df2\u6709MR\u5206\u6790\u7684\u51c6\u786e\u7387\uff1b<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    STROBE-MR\u8d28\u91cf\u8bc4\u4f30\u51c6\u786e\u7387\uff1b<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    GWAS\u9009\u62e9\u6027\u80fd\uff08Precision\/Recall\/F1\uff09<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    \u5c55\u793aMRAgent\u4e0e\u4eba\u5de5\u5728\u5404\u6b65\u9aa4\u8017\u65f6\u5bf9\u6bd4LLM\u5e73\u5747\u63d0\u901f\u4e0a\u767e\u500d\uff1b\u4eba\u5de530\u5206\u949f\u7684\u4efb\u52a1\uff0cMRAgent\u4ec5\u9700\u51e0\u79d2\uff1b\u7a81\u51fa\u4e86\u7cfb\u7edf\u81ea\u52a8\u5316\u7684\u6548\u7387\u4f18\u52bf<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    \u4e94\u3001\u8bba\u6587\u603b\u7ed3<\/h2>\n\n\n\n

    \u8bba\u6587\u63d0\u51fa\u4e86\u57fa\u4e8eLLM\u7684\u81ea\u52a8\u5316\u56e0\u679c\u77e5\u8bc6\u53d1\u73b0\u6846\u67b6MRAgent\uff0c\u7528\u4e8e\u75be\u75c5\u56e0\u679c\u5173\u7cfb\u7684\u53d1\u73b0\u3002
    (1)\u56e0\u679c\u5bf9\u62bd\u53d6\uff1a MRAgent\u901a\u8fc7PubMed\u68c0\u7d22\u6587\u732e\uff0c\u5229\u7528LLM\u63d0\u53d6\u201c\u66b4\u9732\u2013\u7ed3\u679c\u201d\u5bf9\uff0c\u5e76\u8bb0\u5f55\u662f\u5426\u8fdb\u884c\u8fc7\u56e0\u679c\u5206\u6790\u3002
    (2)\u6587\u732e\u8bc4\u4f30\uff1a \u81ea\u52a8\u68c0\u67e5\u6587\u732e\u4e2d\u662f\u5426\u5df2\u6709MR\u5206\u6790\uff0c\u5e76\u8bc4\u4f30\u5206\u6790\u8d28\u91cf\uff0c\u907f\u514d\u91cd\u590d\u5206\u6790\u6216\u9057\u6f0f\u91cd\u8981\u56e0\u679c\u5bf9\u3002
    (3)GWAS\u6570\u636e\u5206\u6790\uff1a \u81ea\u52a8\u9009\u62e9OpenGWAS\u6570\u636e\uff0c\u8fdb\u884cMR\u5206\u6790\uff0c\u751f\u6210\u8be6\u7ec6\u62a5\u544a\u3002<\/p>\n\n\n\n

    \u516d\u3001\u5bf9\u9f50\u601d\u8003<\/h2>\n\n\n\n

    (1) \u67b6\u6784\u5347\u7ea7\uff1a\u53d7 MRAgent \u667a\u80fd\u4f53\u4e09\u5c42\u7ed3\u6784\uff08Brain\u2013Memory\u2013Toolkit\uff09\u542f\u53d1\uff0c\u5c06\u7ecf\u7edc\u2013\u514d\u75ab\u56e0\u679c\u7cfb\u7edf\u4ece\u7ebf\u6027\u6d41\u7a0b\u5347\u7ea7\u4e3a\u5177\u5907\u81ea\u6211\u89c4\u5212\u4e0e\u53cd\u9988\u7684\u95ed\u73af\u67b6\u6784\u3002<\/p>\n\n\n\n

    (2) \u52a8\u6001\u8bc4\u4f30\uff1a \u501f\u9274 MRAgent \u7684\u4eba\u5de5\u51b3\u7b56\u6811\u8bc4\u4f30\u65b9\u6cd5\uff0c\u5f15\u5165\u52a8\u6001\u8bc4\u4f30\u673a\u5236\uff0c\u4f7f Evidence Triangulation \u4ece\u9759\u6001\u52a0\u6743\u8f6c\u4e3a\u81ea\u9002\u5e94\u5224\u65ad\u3002
    (3) \u6d41\u7a0b\u6807\u51c6\u5316\uff1a\u53c2\u8003 MRAgent \u7684\u7aef\u5230\u7aef\u75be\u75c5\u6848\u4f8b\u5c55\u793a\uff0c\u4ee5\u6807\u51c6\u5316\u201c\u9ad8\u8840\u538b\u2013\u7729\u6655\u201d\u6d41\u7a0b\u590d\u523b\u9a8c\u8bc1\u94fe\uff0c\u63d0\u5347\u4e86\u7cfb\u7edf\u7684\u5b8c\u6574\u6027\u4e0e\u53ef\u5bf9\u6bd4\u6027\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u6765\u6e90\uff1aBriefings in Bioinformatics \u4f5c\u8005\uff1aWei Xu\u3001Gang Luo\u3001Weiyu […]<\/p>\n","protected":false},"author":61,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4146","post","type-post","status-publish","format-standard","hentry","category-events"],"_links":{"self":[{"href":"https:\/\/www.15zhi.net\/blog\/wp-json\/wp\/v2\/posts\/4146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.15zhi.net\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.15zhi.net\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.15zhi.net\/blog\/wp-json\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/www.15zhi.net\/blog\/wp-json\/wp\/v2\/comments?post=4146"}],"version-history":[{"count":1,"href":"https:\/\/www.15zhi.net\/blog\/wp-json\/wp\/v2\/posts\/4146\/revisions"}],"predecessor-version":[{"id":4158,"href":"https:\/\/www.15zhi.net\/blog\/wp-json\/wp\/v2\/posts\/4146\/revisions\/4158"}],"wp:attachment":[{"href":"https:\/\/www.15zhi.net\/blog\/wp-json\/wp\/v2\/media?parent=4146"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.15zhi.net\/blog\/wp-json\/wp\/v2\/categories?post=4146"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.15zhi.net\/blog\/wp-json\/wp\/v2\/tags?post=4146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}